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Tamiflu mail order in us
Including against “bird flu” (H5N1), against “swine flu” (H1N1, California Influenza)
Dosage regimen:
Adults and children over 12 years, drug prescribed, 75 mg 2 times / day oral for 5 days. Treatment should begin in the first or second day of onset of symptoms of influenza.
Tamiflu can be taken with food or without regard to meals. Some patients tolerated the drug better, if it is taken during meals.
Patients with impaired renal function and the spacecraft is above 30 ml / min to adjust the dose is not necessary. In patients with CC less than 30 ml / min is recommended to reduce the dose of Tamiflu 75 mg 1 time / day for 5 days. In patients with renal insufficiency (CC less than 10 ml / min) application of the drug was not studied, so when his appointment to be careful.
Patients with hepatic impairment dose adjustment is required.
Patients Senile dosage adjustment is required.
Side effects:
The most frequent adverse events in 1887 patients (including patients treated with Tamiflu, 75 mg 2 times a day, 150 mg 2 times / day and placebo) in controlled clinical trials were nausea and vomiting. They were transient in nature and occurred usually after the first dose. In most cases, these reactions did not require discontinuation of the drug. When you receive the recommended dose (75 mg 2 times / day), nausea and vomiting caused dropouts from the study of 3 and 3 patients, respectively.
Studies have been conducted on the prevention of influenza by receiving the drug at a dose of 75 mg 2 times / day for 6 weeks. This raises the same types of adverse events, as in studies for the treatment of influenza.
Contraindications:
- Hypersensitivity to the drug.
Pregnancy and lactation:
Currently, data on the use of the drug during pregnancy is insufficient to assess the teratogenic effects or fetotoxicity of oseltamivir phosphate.
With this in mind, Tamiflu should be prescribed during pregnancy or during lactation only if the anticipated benefits from its use outweighs the potential risk to the fetus or infant.
Cautions:
Profile of unwanted side effects in patients at risk was, in general, the same as in adult patients with younger age, without concomitant diseases.
Use in Pediatrics
Safety and efficacy of Tamiflu in children under 12 are not installed.
Overdose:
At present, cases of overdose is not described.
Estimated symptoms of acute overdose: nausea with vomiting or without her.
Single doses of Tamiflu to 1000 mg was well tolerated, with the exception of nausea and vomiting.
Drug Interactions:
Information obtained in the pharmacological and pharmacokinetic studies of oseltamivir phosphate, can be considered clinically significant drug interactions unlikely.
Drug interactions due to competition for active centers of esterases, transforming oseltamivir phosphate in the active substance in the literature not covered in detail. Low binding of oseltamivir and the active metabolite of proteins do not suggest the existence of interactions associated with the displacement of drugs from its association with proteins.
Experiments in vitro have demonstrated that neither oseltamivir phosphate, or an active metabolite is not the preferred substrate for multifunctional cytochrome P450 oxidase system or glyukuroniltransferaz. The formal basis for interaction with hormonal oral contraceptives no.
Cimetidine, a nonspecific inhibitor of cytochrome P450 isozymes, competing in the process of tubular secretion of alkaline drugs such as having the properties of cations does not affect the concentrations of oseltamivir and its active metabolite in plasma.
Clinically significant drug interactions based on competition in the renal tubular secretion are unlikely, because of the peculiarities of elimination of active metabolite (glomerular filtration and anionic tubular secretion), and removes the ability of these two paths, as well as a large pool of safety of Tamiflu. Concurrent administration of probenecid increases the AUC of active metabolite of approximately 2-fold due to inhibition of active tubular secretion in the kidneys. However, dose adjustment, while the application of probenecid is not required.
Simultaneous treatment with Tamiflu with paracetamol has no effect on plasma concentrations of oseltamivir, its active metabolite, and paracetamol.
In Phase III clinical Tamiflu prescribed with ACE inhibitors (enalapril, captopril), thiazide diuretics, penicillin, cephalosporins, azithromycin, erythromycin, doxycycline, blocking histamine H2 receptors (ranitidine, cimetidine), beta-blockers (propranolol), xanthine ( theophylline), sympathomimetics (pseudoephedrine), codeine, GKS, inhaled bronchodilators, analgesics, antipyretics and NSAIDs (acetylsalicylic acid, ibuprofen and paracetamol). Changes in the nature or frequency of adverse events while not observed.
