Buy Dapsone online

Pharmacological action dapsone cream

Protivoleproznoe means of sulfones. Has bacteriostatic action. The mechanism of action due to inhibition of synthesis of folic acid in parasites. It is active against a broad spectrum of microorganisms, but mainly against Mycobacterium leprae, and Plasmodium, Pneumocystis carinii, dapsone dosage.

Pharmacokinetics

Slowly absorbed from the gastrointestinal tract. Bioavailability – 70-80%. It is well distributed in the body, but particularly high concentrations are in liver, muscle, kidney and skin. Concentration in saliva – 18-27% of the concentration in the blood. Good crosses the dapsone for cliac disease placental barrier. Tmax – from 2 to 6 h. When used in single doses of 50 and 100 mg Cmax of 0.6-0.7 and 1.7-1.9 mg / ml, respectively.

Is metabolized in the liver with the acetyltransferase with the order dapsone formation of metabolite – monoatsetildapsona, which may be subjected to deacetylation and go back to dapsone. The equilibrium between them is created in a few hours. The rate of acetylation depends on how acetylators is a patient – “fast” or “slow”, with the rate of acetylation of the clinical effectiveness of therapy is not defined. Another way of its metabolism – a hydroxylation in the liver to dapsongidroksilamina order online dapsone.

Binding dapsone plasma protein – 70-90%, and monoatsetildapsona – more than 90%. T1 / 2 for dapsone and monoatsetildapsona – 10-50 hours (average about 30 h). 70-85% slowly excreted by the kidneys in the form of dapsone and its metabolites (5-15% dapsone is obtained by active tubular secretion), the remainder is excreted in the form of metabolites, buy online dapsone which are partly conjugated with glucuronic and sulfuric acids. Enterohepatic circulation is essential for the maintenance of certain concentrations of the drug in the blood during prolonged therapy.

Indications

In the combined therapy: treatment and prevention of all forms of leprosy, malaria prevention, treatment and prevention of pneumocystis pneumonia, toxoplasmosis prophylaxis, treatment of cutaneous leishmaniasis.

Dosage regimen

Dosage and individual. In the combined therapy is used in a dose of 50-100 mg / day or 1-2 mg / kg / day. If necessary, the maximum daily dose is 300 mg. Treatment of long-term.

Side effects

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The part of the hemopoietic system: possible hemolytic anemia, methemoglobinemia (when receiving a daily dose of more than 200 mg), agranulocytosis.
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From the digestive system: rarely – nausea, vomiting, hepatitis. Dermatological reactions: skin rash, exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome.

Other: headache.

Contraindications

Severe anemia, increased sensitivity to dapsone.

Pregnancy and lactation

If you want to use dapsone during pregnancy should be related to the alleged benefit to the mother and the potential risk to the fetus. Dapsone is excreted in breast milk. Therefore, if necessary, use during lactation should decide the issue of termination of breastfeeding.