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Effects of Viagra starts half an hour after the adoption, the duration of not less than 6 hours.
The active ingredient sildenafil increases the amount of blood in the penis, expanding the blood vessels, and causes a healthy erection. Sildenafil acts in a natural way, that is, then when a man feels sexual excitement.
The use of Viagra:
* Valid for 6-8 hours;
* Increases the sensitivity of nerve endings of the penis;
* Accelerates the recovery process after the last sexual intercourse;
* Enhanced sexual desire and desire;
* The rapid flow of the active ingredients of the drug in the blood;
* Restores sexual desire;
* Increases your stamina and sex drive;
* Multiplies the number and quality of orgasms;
* Psychological self-confidence;
* Helps to even the most difficult cases of erectile dysfunction.
How to
Take Viagra should be washed down into the water, about 15-20 minutes before sexual intercourse. The maximum daily dose of 100 mg.
With Viagra you will have a most powerful erection ever been, a desire to be extremely strong, you feel as if you re 20 years. You no longer need to spend a lot of time to proceed, as before, just one touch and you are ready to plunge into the ocean of sexual fantasies and desires.
It should also be noted that, if you have pharmaceutical Viagra after a meal in McDonald’s, or eating other fatty foods (such as fish and chips, cheeseburger or fries), the effect of Viagra may come a little longer than usual. At this time, you can talk with your partner for some time until the drug begins to act and not give the desired effect.
Pharmacological action
Viagra relaxes the smooth muscles active corpus cavernosum and increases blood flow to the penis, it causes a man a firm erection and sexual readiness. This is facilitated by a specific enzyme (protein that assists chemical reactions) characteristic only for the brand Viagra. That is the enzyme that normally separates the chemical components that cause erectile response.
By blocking the collapse erectile chemicals, Viagra causes prolonged erection of the penis. The drug works only when a man experiencing a natural sexual arousal in the absence of stimulation, the man did not come erection.
If you feel that you lose power in their sexual life, please do not hesitate, do not worsen your situation, and do not make your life even worse. Pfizer Viagra cure your self-doubt and restore your sex life. Do not waste your time! Buy Viagra pill you can right now!
Tips Viagra Admission
If you missed medication, should take the pill as soon as possible. If you still prefer to regularly take medication “Viagra” he remembered receiving the drug at the wrong time, it is better to skip the reception and return to your regular mode of reception. Do not take more than 100 mg per day.
Storage:
Pfizer Viagra Store at room temperature, 68-77 ° F (20 -25 ° C). Avoid high temperature, humidity, and light. Keep out of reach of children and pets site.
Contraindications Viagra
Should not buy Viagra if:
* Do you have an allergy to any component that is part of Viagra;
* Your doctor has forbidden you to be sexually active due to the presence of cardiovascular diseases;
* You are taking medications containing nitrates to treat angina (eg, isosorbide dinitrate, nitroglycerin, nitroprusside) in any form (eg, tablet, capsule, patch, ointment, etc.);
* You are taking certain regional drugs called poppers (eg, amyl nitrite, butilnitrit, Iso-butylnitrite).
You should seek emergency medical help if you took the drug together with the above drugs.
Particularly important:
* Viagra can cause: dizziness, drowsiness, fainting, or blurred vision. These side effects may worsen if you are taking medication with alcohol or certain medicines. Do not drive or perform other tasks that require special care, as long as you do not know what effect on you has a pharmaceutical product Viagra.
* Viagra can cause: dizziness, loss of consciousness or fainting, alcohol, hot weather, exercise, or fever may exacerbate these side effects. To prevent them, should sit up, get up slowly, especially in the mornings. Immediately sit down or lie down at the first sign of any of these side effects.
* Patients with heart disease who take Viagra Pfizer, might increase their risk of getting side effects associated with the heart, including heart attack or stroke.
Symptoms of a heart attack may include: pain in the chest, shoulder, neck, or jaw, numbness in hands or legs, severe dizziness, headache, nausea, stomach pain, or vomiting, fainting, or changes in vision.
Symptoms of stroke may include: confusion, change in vision or speech changes, weakness, or fainting. Urgent appeal to your doctor or health service, if you are experiencing these symptoms.
* Viagra may cause prolonged, painful erection (priapism). This can happen even if you did not have sexual contact. If an erection for a long time does not pass, it could lead to permanent sexual problems such as impotence. Contact your doctor immediately if you had a long (more than 4 hours) and painful erection.
* Do not take other medicines for the treatment of erectile dysfunction with Viagra.
* Viagra does not stop the spread of HIV or other sexually transmitted diseases, sexually transmitted diseases. Use of contraceptives for birth control (eg, condoms), or, if you have HIV infection or other sexually transmitted diseases, sexually transmitted.
* Viagra is not a contraceptive. If your partner is able to get pregnant and you wish to avoid pregnancy, be sure that you use an effective form of contraception (eg condoms).
* Older people should be cautious to take Viagra because of increased sensitivity to the ingredients.
* Viagra is not recommended to apply to children under 18 years of safe and effective use in children has not been confirmed.
* Pregnancy and breast-feeding: not approved for use in women.
Side effects of Viagra:
If you have seen any of the following serious side effects, you should immediately stop taking Viagra and seek emergency medical attention:
* An allergic reaction to the drug Viagra (shortness of breath, dyspnea, total or partial closure of the airways, swelling of lips, tongue, or face, or hives);
* Chest pain or cardiac arrhythmia;
* Swelling of the ankles or legs;
* Shortness of breath;
* Prolonged or severe dizziness;
* A prolonged (duration more than 4 hours) or painful erection (priapism);
* Dizziness, nausea, or angina (pain, tightness of breath, discomfort, numbness, tingling or pain in the chest, arms, neck, or jaw).
Other, less serious side effects of Viagra, more common, and usually pass with time (several hours). You can continue to receive safer sex and avoiding, but consult with your doctor if you experience:
* Rush of blood to the face, redness;
* Moderate dizziness;
* Headache;
* Runny nose, nasal congestion;
* Loose stools;
* Temporarily change color, the predominance of blue or green shades, or other changes in vision;
* Itching or a rash.
Also there may be other side effects, in addition to the above. Consult with your doctor about any side effects that you think is unusual, or it causes you discomfort.
Interesting information about Viagra
As shown by clinical studies the drug Viagra has been effective in most cases of erectile dysfunction in men. In clinical studies, in 37 out of 40 men with erectile dysfunction had improved erections with the highest dose of Viagra, which is 100 mg.
If you feel that you have already lost power in their sexual life, please do not hesitate in his decision not to aggravate your situation, and do not make their lives worse. Only Viagra cure your self-doubt and restore your sex life. Do not waste your time! Buy Viagra, you can have us right now!
Customer Information
How to order Viagra?
1. add product to cart
2. go to ordering
3. select delivery method
4. complete data for sending the order, then you will be contacted by e-mail our representative to confirm your order
5. Pay and receive goods
By purchasing from our online shop twenty or more tablets of Viagra, you get a gift. Cost depends on the number of Viagra tablets in the package
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Viagra is a new oral medication for the treatment of erectile dysfunction. He restores impaired erectile function and provides a natural response to sexual stimulation.
The physiological mechanism of erection of the penis involves release of nitric oxide (NO) in the cavernous body during sexual stimulation. Does viagra really work activates the enzyme guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate (cGMP), relaxation of corpus cavernosum smooth muscle and increase blood flow to the penis.
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for the breakdown of cGMP in the cavernous body. Viagra has a peripheral effect on erections. Sildenafil has no direct relaxing effect on corpus cavernosum, but also actively enhances the relaxing effect of cheap viagra in uk on this tissue. When activated, the way NO / cGMP, which persist in sexual arousal, inhibition of PDE5 under the influence of sildenafil increases the levels of cGMP in the cavernous body. In this regard, for the manifestation of a favorable pharmacological effect of Viagra requires sexual stimulation.
In single dose of Viagra oral doses up to 100 mg in healthy volunteers, the drug did not cause clinically significant changes in ECG. The maximum decrease in systolic blood pressure in the prone position when using the online viagra order orally at a dose of 100 mg averaged 8.4 mm Hg. Art. The corresponding decrease in diastolic blood pressure in the prone position was 5.5 mm Hg. Art. Reduction in blood pressure due to vasodilating effects of sildenafil, probably by increasing the level of cGMP in vascular smooth muscle.
Viagra has no effect on visual acuity and contrast perception. Some patients at 1 h after dosing at 100 mg revealed a slight and temporary violation of color discrimination (blue / green) with the test Farnsworth-Munsell 100; 2 hours after taking the drug, these changes were absent. The proposed mechanism of violations of color vision see FDE6 oppression, which is involved in the transmission of light in the retina. Studies in vitro have shown that the effect of viagra results on FDE6 10 times inferior to its activity against PDE5.
Studies in vitro suggest that the activity of sildenafil against PDE5 10 -10 000 times higher than its activity against other isoforms of phosphodiesterase (PDE 1, 2, 3, 4 and 6). In particular, the activity of viagra price against PDE5 of 4 000 times greater than its activity against FDE3 – cAMP-specific phosphodiesterase involved in the reduction of the heart.
3.1.1. Additional information about clinical trials
Efficacy and safety of Viagra has been studied in 21 randomized, double-blind, placebo-controlled study lasting up to 6 months. Viagra used more than 3000 patients with erectile disorders of various outdated viagra (organic, psychogenic, mixed) aged 19 to 87 years. Effectiveness was determined on the basis of overall assessment, diaries, recording erections, assessing the international index of erectile function (IIEF, a questionnaire designed to assess sexual function), and survey partners.
The effectiveness of Viagra, which was estimated by the ability to provide advance preparation and conservation of an erection sufficient for sexual intercourse, was demonstrated in all over the counter viagra and persisted during long-term treatment (one year). When using fixed-dose proportion of patients reported improvement in erectile function, was 62% (25 mg), 74% (50 mg) and 82% (100 mg), while placebo – 25%. In addition to improving erectile function, IIEF analysis showed that treatment with Viagra improves as orgasm, satisfaction with sexual intercourse and overall satisfaction.
In all studies, the proportion of patients with diabetes mellitus, indicating improvement in the treatment of Viagra, accounted for 59% of patients after radical prostatectomy – 43% of patients with spinal cord injury – 83% (versus 16%, 15% and 12% of patients receiving placebo, respectively).
3.2. Pharmacokinetic properties
Suction
Viagra is rapidly absorbed. The concentration of drug in plasma after taking it inside an empty stomach reaches a peak within 30-120 min (average 60 minutes). Absolute oral negative effects viagra averages 41% (25-63%). Pharmacokinetics Viagra when administered in the recommended dose range (25-100 mg) is linear.
When you receive Viagra in combination with fatty food intake rate decreases; Tmax is increased by 60 min, and Cmax decreased by an average of 29%.
Distribution
The volume of distribution (Vss) Sildenafil at steady state an average of 105 liters, indicating that its distribution in tissues. Sildenafil and its major circulating N-desmetilovy metabolite approximately 96% bound to plasma proteins. Protein binding is not dependent on the total concentration of the levitra versus viagra.
In healthy volunteers who received Viagra (single dose of 100 mg), less than 0.0002% (average 188 ng) dose was found in semen after 90 min after administration.
Metabolism
Sildenafil is metabolized primarily by CYP3A4 (major route) and CYP2C9 (optional path) of the liver microsomal isoenzymes. The main circulating metabolite formed by the N-desmetilirovaniya Sildenafil. On the selectivity of action on PDE metabolite herbal viagra reviews with sildenafil, and its activity against PDE5 approximately 50% of the activity of the drug. Metabolite concentration in plasma is approximately 40% from those of sildenafil. N-desmetilmetabolit undergoes further metabolism; terminal during its half-life is about 4 hours
Withdrawal
The total clearance of sildenafil from the body is equal to 41 l / h and terminal elimination half-life – 3-5 hours after oral or intravenous administration of sildenafil is excreted as metabolites primarily in the faeces (approximately 80% of the administered dose) and to a lesser extent in cheapest viagra anywhere ( approximately 13% of the administered dose).
Pharmacokinetics in special groups of patients:
Seniors
In healthy elderly volunteers (65 years and older) sildenafil clearance was reduced, and the concentration of free drug substance in the plasma by approximately 40% higher than its guaranteed cheapest viagra in healthy young volunteers (18-45 years). However, analysis of safety data showed that age does not influence the frequency of adverse events.
Renal failure
In volunteers with mild (creatinine clearance 50-80 ml / min) and moderate (creatinine clearance 30-49 ml / min) renal insufficiency Viagra pharmacokinetics after a single oral administration (50 mg) did not change. In volunteers with viagra for sale without a prescription (creatinine clearance <= 30 ml / min) renal clearance of sildenafil decreased, which led to an increase in AUC (100%) and Cmax (88%) compared with those of volunteers, matched for age, which did not suffer a violation kidney function.
