Skin Diseases

In no field of medicine, there is probably a variety of diseases and their manifestations, as in dermatology – the science dealing with the study of our skin. Some diseases such as psoriasis, atopic dermatitis, eczema, occur very frequently. Others (eg, erizepiloid or bullous dermatitis) are extremely rare.

But why often dermatologists prescribe for such seemingly different diseases are the same medicine?

The thing in common pathogenesis of the disease, ie stereotipizme reactions of the human body. Leather (like all other tissues of the human body) can only marvel at the four types of pathological reactions: inflammatory, allergic, degenerative and autoimmune. The latter are very complex response mechanisms, and to influence them is virtually impossible.

Let’s deal with the other three:

1. Inflammation (underlies all infectious processes – erysipelas, pyoderma, acne, boils, herpes, eczema and other). The essence of the process that a bacterial or viral pathogen is introduced into the unprotected skin (weakening of the immune, hormonal imbalance, microtrauma) and causes a reaction in the form of activation of blood cells, a local (or general) rise in temperature, swelling, itching. Since our body fights infection.

2. Allergies (link leads to diseases such as urticaria, household rash, insect bites, an important link within diathesis, all childhood dermatitis, neurodermatitis, eczema and psoriasis). Our body recognizes the particles of matter that fall to us with food, air, water – as alien and harmful, and runs the cellular and molecular mechanisms of their destruction, as demonstrated redness, swelling, itching, and fever and more serious disorders. Neuropsychiatric adverse factors (stress, depression, fatigue) only reinforce the allergic reaction.

3. Degeneration (manifested in lupus, trophic ulcers, in elderly patients, often with psoriasis). Due to poor blood circulation caused by senile changes, vascular disease and nerve violated trophic (nutrient) processes of tissues, and protein structure of the skin begin to deteriorate. Damaged products are vital to the work displayed through the pores, and often simply “clog up” tissues, causing all the same symptoms: peeling, itching, swelling.

Thus, it becomes clear that it is necessary to influence the same links of pathogenesis, to cope with the huge spectrum of skin diseases. The product “Propolis Geliant” perfectly suited to this due to its composition. It has a bactericidal and anti-inflammatory action, is struggling with allergies (except those allergic to honey and bee products), contributes to the rapid provision of decay products and degeneration of the skin. Equally important, the drug is able to cut short manifestation (symptoms) of diseases such as itching, swelling, redness skin.

Let us consider the effect of “Propolis Gelianta” on the skin:

Anti-inflammatory effect of the drug is due mainly inhibitory activity (mainly due to flavonoids, diterpenes klerodanovyh, isomers 2-klerodanditerpena, coniferyl alcohol, caffeine acid and its esters, etc.) on prostaglandinsintetazu, thus inhibited the synthesis of prostaglandins, which are important components of the inflammatory response.

Antiallergenic and antipruritic effect of the drug due to the fact that flavonoids have the ability to block calcium channels in mast cells. In this way they prevent the release of histamine, which is almost always the responsibility of immediate-type allergic reactions, accompanied by itching.

Antimikotichesky effect of the drug based on the direct fungicidal action (being a part of compounds: galangina, kaempferol, pinotsembrina, caffeic acid and allicin in relation to a wide range of fungi (Candida albicans, Trichophyton rubrum, Microsporum canis, etc.). In addition, the drug activates the cellular immune response, contributes to the activation of phagocytosis in macrophages contributes to its completion.

Antivirus action of the drug achieved its constituent flavonoids. Their activity against the polio virus, Herpes-type virus and adenovirus is well known. Antiviral effect and other components have a drug – esters of caffeic acid, Chrysin, kaempferol. In addition, Chrysin and kaempferol actively affect the adenovirus and rotavirus, hepatitis B virus Izopentilferulat inhibits the replication of influenza virus.

Antibacterial and Antiprotozoal activity of the drug action is conditioned cinnamic acid, some of aromatic molecules and the majority of flavonoids, comprising one of the components of the product – an extract of propolis. The extract of propolis inhibits the reproduction of microbes, preventing cell division and causing destruction of the cell wall of bacteria. The most important antibacterial activity observed against gram positive and less pronounced – for Gram-negative microorganisms.

Antioxidant activity of the drug carried a list of 38 known and identified flavonoids, directly preventing the oxidation of lipids, activation geksozomonofosfatnogo shunt and excessive production of toxic oxygen radicals neutrophil granulocytes in peripheral blood.

Local analgesic effect of the drug is mediated by the activity of aromatic esters of propolis, similar in structure to local anesthetics of novocaine. Experimental and clinical studies indicate that the local analgesic activity of propolis in the novocaine than 5,2 times.

Trophic action and stimulation of reparative processes regeneraratsii tissues due to the ability to accelerate growth and maturation of granulation tissue (due to the production of extracellular matrix and fibrillar proteins, fibroblasts, endothelial proliferation and growth of capillaries) and epithelization of the wound surface.

Finally, nutrients, amino acids, vitamins and trace elements that make up the drug, contribute to healthier tissues. Phenolic acids and some amino acids, for example – proline (which is involved in the synthesis of collagen and elastin – the factors contributing to the elasticity of the skin) or arginine (which stimulates cell division, cell renewal).

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