Fapmakologicheskoe action:
Immunosuppressive agent. -Factor for the synthesis of RNA and DNA, inhibits the expansion of immunocompetent cells, dependent on the T-cell immune response.

Indications:
Prophylaxis of transplant rejection reactions (in the combined therapy). Rheumatoid arthritis is a heavy flow, chronic hepatitis, systemic lupus erythematosus, dermatomyositis, periarteritis nodosa, vulgar pemphigus, idiopathic thrombocytopenic purpura, acquired hemolytic anemia, pyoderma gangrenosum.

Mode dozipovaniya:
Set individually based nosological form and severity of illness, dosage of both drugs that haematological tolerability. For the prevention of graft rejection reactions appoint a shock dose of 5 mg / kg / day in 2-3 doses for 1-2 months, then move on to maintenance dose of 1 to 4 mg / kg / day for several years. In other cases, the daily dose of 1-2.5 mg / kg. Treatment of long-term.

Side effects:
Mielodepressiya (leukopenia, thrombocytopenia, anemia), development of secondary infections, megaloblastic erythropoiesis and macrocytosis, nausea, vomiting, anorexia, skin rash, arthralgia, myalgia, drug fever, cholestatic hepatitis. In transplant recipients marked pancreatitis, erosive and ulcerative lesions and bleeding from the digestive tract, necrosis and perforation of the intestine. There are few reports on the development of acute renal failure, hemolytic anemia, acute lung disease, meningeal reactions.

Ppotivopokazaniya:
Pregnancy, hypersensitivity to azathioprine and / or mercaptopurine.

Cautions:
During the first 8 weeks of treatment shows a picture of a weekly control of the peripheral blood after – 1-2 times a month. Patients with impaired renal function and / or liver, and while receiving allopurinol should be prescribed lower doses of azathioprine.