NEW DRUGS FOR TREATMENT OF ERECTILE DYSFUNCTION

What is erectile dysfunction?
Anatomy of an erection
Revolutionary event in the treatment of erectile dysfunction was the appearance in 1996, the drug sildenafil citrate, has become known under the trade name “Viagra”. This drug, taken orally in a tablet form, increased the effectiveness of treatment and provided an opportunity for general practitioners to help patients with ED. However, many men, especially with severe erectile dysfunction, diabetes, arterial hypertension, and patients who had undergone radical prostatectomy, is not fully satisfied with the existing treatment. In addition, the effect of sildenafil depends on eating and drinking, often victims of sexual components, which creates some problems with the planning of sexual intercourse. These circumstances lead to the fact that on average only 50% of patients taking sildenafil, intend to continue treatment.

The causes of erectile dysfunction
Next approved the use of PDE5 inhibitor sildenafil has become after the drug “Cialis (tadalafil). In contrast, sildenafil the drug has a long half-life (17.5 h) and its pharmacokinetics is independent of food intake and alcohol. Thus, the duration of Cialis (36 h) allows comfortable with the so-called planning a sexual act and keep the spontaneity and romance of sexual relations. However, recent studies show that only 13% of patients with buying ed drugs online are interested in the duration of action of drugs and mainly interested in reliability (40%) and safety (40%) received therapy. In addition, some patients taking tadalafil, marked side effects such as back pain, and some of them these signs continue for as long as the drug acts. Cialis is available in a single dose (20 mg), which creates some problems with the correction of the therapy depending on the effectiveness and tolerability.

Methods of treatment of erectile dysfunction
Thus, a certain number of patients dissatisfied with the previous treatment of ED, as well as a large number of patients with undiagnosed and untreated disorders of erection, in need of a new, more effective drugs. Ideal therapy for ED is noninvasive, ie, involve administration of oral medication, is a highly portable treatment, is equally effective in all populations. All the above requirements among the existing products in the best preparation “Levitra (vardenafil hydrochloride) – a new, highly efficient and the most potent inhibitor of PDE5. Vardenafil for the influence of sildenafil on PDE5 stronger in more than 10 times. Vardenafil has less compared with sildenafil effect on the light effect and smaller compared with sildenafil and tadalafil effect on spermatogenesis.

Vardenafil is rapidly absorbed, maximum concentration of drug in blood plasma is reached after an average of 30 minutes after oral administration. Duration of the drug, Levitra, 4-5 h, which is sufficient for full sexual intercourse, and does not result in the accumulation of the drug in humans. This is printsipialynym difference from tadalafil, a significant long half-life which is to cause harmful effects in the daily admission. The effectiveness of the drug did not affect food intake and alcohol.

The clinical study showed that vardenafil is highly effective (85-89%) and safe drug attraction ED. More powerful effect of this drug on PDE5 can be used not only in the general population, but when no other effective PDE5 inhibitors (sildenafil, tadalafil). The effectiveness of the drug, Levitra, patients with diabetes mellitus and after radical prostatectomy is 72%, and in patients previously unsuccessfully taking sildenafil – 62%.

Side effects while taking Levitra in most cases short-lived and insignificant.

Thanks to these properties of the drug as a rapid and pronounced effect, independent of food intake and alcohol, patients will be able to plan the sexual act at any convenient time. The product is available in three doses (5,10 and 20 mg), which allows a doctor to carry out correction therapy, depending on its effectiveness and tolerability. These and other differences from Viagra, such as the lack of effect of tachyphylaxis (loss of efficiency in the long-term therapy), give great hope for long-term treatment of ed trial pack.

Thus, existing today drugs to treat erectile dysfunction can get positive results in most patients. Unfortunately, leaving a portion of buy pharmacy ED patients who have either ineffective pharmacotherapy. In these patients used other treatments (combined oral and intrakavernoznaya therapy vakuumterapiya, surgical treatments).

Pill identification wizard

Erection it – increasing the penis with increased elasticity.

(from the Latin erigo, erectum – raise, erect, construct) an pill identification in the volume of the penis with a sharp increase in its elasticity. Creates an opportunity for the introduction of the penis into the vagina and the implementation of sexual pill identifier (coitus).

Most stress the penis occurs under the influence of mental stimuli (visual, auditory, olfactory, tactile), which entered the cerebral cortex, subcortical stimulate sexual centers, and then excite the erection center in the spinal cord. Erections can occur by mechanical stimulation of the weight loss pills penis, under the influence of sexual attitudes and fantasies, causing the man’s sexual arousal, increase in erection.
Natural remedies to increase erection powerful increase in potency! Strengthening of male health.

Under the action of pulses arriving along the nerve fibers directly to the penis, is expanding the lumen of the arteries that supply it with blood. This dramatically increases flow of arterial blood to the head of the penis and cavernous (cavernous) bodies, and the venous diet pills is slowing. As a result, the blood quickly fills the spongy tissue cavernous bodies with an increase in their volume by 3-4 times. Simultaneously, there is strain and straightening of the penis, increasing erection.

After the development of erectile the blood flow in arteries nourishing balanced with its venous outflow from the corpora cavernosa, which preserves the necessary for sexual intercourse voltage erect penis. Head of the penis, even in a state of full erection is elastic and prevents injury to female genital mutilation. After ejaculation and orgasm, or in a pills identifier that excludes sexual intimacy, increased venous outflow from the cavernous bodies with a gradual decline in the inflow of arterial blood pressure and volume of the penis begin to decrease.

Time of complete relaxation of the penis depends on the influence of many external stimuli, which contribute to the morning after pill of sexual arousal or, conversely, distract men from their sexual reactions.

For example, loss of erection after ejaculation occurs more slowly, if the penis remains in vagina, as in this case continues its stimulation due to direct contact of the penis and identify pill markings.
The first phase of erection

The first phase erektsiiVenets glans penis, erection, raising eggs, the appearance of “goose skin” – a weak pill id an erection.
The second phase of erection

The second phase erektsiiUvelichenie in the size of the glans penis, the crown of the glans penis, Cowper’s gland secretion drops, the increase in testis, testicular elevation, the appearance of “goose skin”
The third phase of erection

The third phase erektsiiSokraschenie muscles of the seminal vesicles and prostate gland – the first phase of an orgasm, contraction of the muscles of the penis and urethra – the second phase of orgasm, the crown of the glans penis, the sphincter muscles of the anus, the appearance of “goose skin”
The fourth phase of erection

The fourth phase erektsiiVenets glans penis, the decrease in testis, testicular descent, scrotal relaxation
Erection, erection enhancement, erection problems
Preparations for the increase erection + increase in members for the course, increased potency! Strengthening of male health. No surgical

Erectile Dysfunction has many names, but most of them did not reflect the nature of the disease. Many men are not impotent: they only have an erection problem – gain an erection, which are easily eliminated. The word “impotence” implies a complete failure of erection. The terms “periodic” or “secondary” impotence say that the violation of erection began recently, until the erection was quite satisfactory. The term “Erection Dysfunction” creates the impression that there are serious problems.

In Western countries, with erectile dysfunction, many men just go to the urologist. The doctor collects all information relating to hereditary diabetes measure blood pressure, pulse and respiration, said the state of secondary sexual characteristics, examines the genitals for the presence of scars resulting from trauma or postponed surgery and penis – in the presence of disease. Then palpable testes, estimating their shape, size and structure. Draws a general analysis and analysis of fasting blood, which eliminates (or reveals) the presence of diabetes.

How to get an erection

Relative elementary mechanism of erection is determined by the least amount of integrable anatomical and physiological structures and the predominance of one of them initially peripheral structures, preserving a significant share of autonomy (spinal, and paraspinalnye priorgannye vegetative nodes and plexus). Significant resistance erections, caused by their protection from the damaging factors “embarrassing erection stories” nature is determined by their reliance on the most ancient phylogenetic structure. That is why of all the manifestations of male sexuality, they are formed and the first detected – well in advance of libido, ejaculation and orgasm, watching the male erection in infancy. But at the same time, it was an erection are extremely sensitive to any kind of stressful influences, which is determined by the controllability of the higher cerebral mechanisms, for example, because negative emotions. vacuum erection device

Erection

Along with this realization that it was an male erections, mythologized, and a fetish for many people (in the form of phallic worship), are a kind of symbol of manhood and male dignity, exacerbate their vulnerability. Erection – vascular reflex act, the basic mechanism of erection due to increased inflow of arterial blood, and slowing the outflow of blood through the veins while playing only a supporting role, while at the same time due to reduction of mm. ischiocavernosi, acting like a lever, a vascular effect is enhanced by a mechanical lift under the penis. The most common strain of the guys locker room erection occurs under the influence of mental stimuli (visual, auditory, olfactory, tactile), which entered the cerebral cortex, subcortical stimulate sexual centers, and then excite the erection center in the spinal cord. Erections can occur by mechanical stimulation of the glans penis, under the influence of sexual attitudes and fantasies, causing the man’s sexual arousal.

In terms of physiology, the mechanism of sensible erection erection fairly accurately studied and a complex chain of neurohumoral processes, which can be divided into three components: 1) increased arterial bed, and 2) relaxation (relaxation), smooth-muscle apparatus of the cavernous bodies, and 3) block venous outflow. The result of all this sequence of events – filling the corpus cavernosum of the penis with blood from an almost complete cessation of its outflow, allowing the penis increase in longitudinal and transverse dimensions and gives new strength (stiffness).

An erection is most important for sexual intercourse. Sluggish, sleeping penis can not enter the vagina. Only elastic form swollen he «agree» log in «business contact» with a woman’s vagina. An erection will begin sexual activity is due to the reflex. With the onset of sexual activity instinctive nature is complemented by an erection of the erection problems opportunities for its conditional reflex mechanism. Various images of women, memories, visual, auditory, and sensory impressions are perceived cortical sexually center men, as a means of further strengthening erections member. All this contributes to sexual arousal and readiness of men to have sex. In the future, the voltage of the penis is supported mainly by mechanical agents, received head and skin member during sexual getting an erection.