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Buy topamax no prescription
Pharmacological action
Antiepileptic drugs, belongs to a class of sulfate-substituted monosaccharides.
Topiramate blocks sodium channels and inhibits the emergence of repetitive action potentials on a background of prolonged depolarization of the membrane of the neuron & buy topamax no prescription.
Topiramate enhances GABA activity against certain subtypes of GABA-receptors (including GABAA-receptor), and modulates the activity itself GABAA-receptor activation prevents kainate subtype of kainate sensitivity / AMPK (alpha-amino-3-hydroxy-5 – metilizoksazol-4-propionic acid) receptors for glutamate, does not affect the activity of N-methyl-D-aspartate (NMDA) on the NMDA-receptor topamax generic subtype. These effects are dose-related drug at a concentration of topiramate in plasma from 1 mmol to 200 mmol, with minimal activity in the range from 1 mmol to 10 mmol. In addition, topiramate inhibits some isoenzymes of carbonic anhydrase activity.
On expression of the pharmacologic effect of topiramate significantly inferior to acetazolamide – a known carbonic anhydrase inhibitor, so this activity of topiramate is not a major component of its antiepileptic activity.
Pharmacokinetics
Suction
After receiving the drug inside topiramate rapidly and efficiently absorbed buy topamax no prescription from the gastrointestinal tract. Bioavailability is 81%. Eating no clinically significant effect on bioavailability.
Following single dose oral pharmacokinetics of topiramate are linear in nature, plasma clearance remains constant, and the AUC in the range of doses from 100 mg to 400 mg increases in proportion to dose.
After repeated oral administration at a dose of 100 mg 2 Cmax average of 6.76 mg / ml.
Distribution
Plasma protein binding is 13-17%.
After a single oral dose to 1200 mg average Vd is 0.55-0.8 L / kg. The value of Vd depends on sex. In women, the values topamax generic are approximately 50% of the values observed in men, which is associated with a higher content of adipose tissue in women.
In patients with normal renal function to achieve equilibrium may require 4 to 8 days.
Metabolism
After oral administration, is metabolized about 20% of the dose.
The plasma, urine and human feces were isolated and identified 6 virtually inactive metabolites.
Withdrawal
Topiramate (70%) and its metabolites are eliminated primarily by the kidneys.
After oral administration, plasma clearance of the drug is 20-30 ml / min.
After repeated administration of the drug for 50 and 100 mg, 2 average T1 / 2 was 21 h.
Pharmacokinetics in special clinical cases buy topamax no prescription
Topiramate kidney excretion rate topamax generic depends on renal function and does not depend on age.
Patients with impaired renal function (CC ≤ 60 mL / min) renal and plasma clearance of topiramate is reduced.
Time to reach equilibrium in patients c moderate to severe impaired renal function from 10 to 15 days.
Elderly patients not suffering from kidney disease, plasma clearance of topiramate is unchanged.
In patients with moderate and severe hepatic impairment the plasma clearance is reduced.
Patients receiving concomitant therapy antiepileptic drugs buy topamax no prescription that induce enzymes involved in the metabolism of drugs, the metabolism of topiramate increased by 50%.
Topiramate effectively displayed by hemodialysis.
Children under the age of 12 years, pharmacokinetic parameters of topiramate as well as in adults receiving the drug as an adjunctive therapy, are linear, while its clearance is not dependent on the dose and Css in plasma increases proportionally with increasing dose. Note that the clearance of topiramate in children increased, and its T1 / 2 shorter. Therefore, when the same dose per 1 kg body weight concentrations of topiramate in plasma in children may be lower than in adults. Children, like adults, antiepileptic drugs that induce hepatic enzymes that cause reduction Css topiramate in plasma.
Indications
Monotherapy:
*
epilepsy (including patients with newly diagnosed epilepsy) in adults and children older than 2 years.
In the complex therapy:
*
partial or generalized tonic-clonic seizures in adults and children older than 2 years;
*
seizures associated with Lennox-Gastaut syndrome, in adults and children older than 2 years.
Capsules 50 mg are also used to prevent migraine attacks (adults).
The use Topamax for treatment of acute migraine attacks is not known.
Dosage regimen
The drug is taken by mouth, regardless of the meal.
To achieve optimal control of epileptic seizures in adults and children is recommended to start treatment with the drug in low doses with subsequent titration to effective dose.
Tablets Topamax is not recommended to divide into parts.
Capsules are intended for patients who have difficulties with swallowing tablets (eg, children and elderly patients).
The capsules should be carefully opened, their contents mixed with a small amount (about 1 teaspoon) of any soft food. This mixture should be swallowed immediately buy topamax no prescription without chewing. Do not store medication mixed with food until the next reception. Topamax capsules may be swallowed whole.
When using Topamax as part of combination therapy with other anticonvulsants in adults, including elderly topamax generic patients with normal renal function, the minimum effective dose is 200 mg / day. Average daily dose is 200-400 mg, number of intakes – 2 times / day.
Selection of doses beginning with 25-50 mg 1 time per day. at night, taking medication for 1 week. The following is to increase the dose by 25-50 mg at intervals of 1 or 2 weeks before the selection of effective dose, number of intakes – 2 If necessary, may increase to a maximum daily dose – 1600 mg. The criterion for selection of dose is the clinical effect. In some patients the effect is achieved when receiving the drug 1 time / day. To achieve optimal effect of treatment
Topamax is not necessarily control its concentration in plasma.
When using Topamax as part of combination therapy with other anticonvulsants in children older than 2 years, the recommended total daily dose is from 5 to 9 mg / kg and was adopted in 2 hours. Selection of the starting dose of 25 mg / day. (or less, the rate of 1-3 mg / kg body weight / day.), take medication at night for 1 week. In the future, with weekly or biweekly intervals dose can be increased by 1-3 mg / kg, and take the drug in 2 hours. The selection of doses should be guided by clinical effect. The daily dose of 30 mg / kg of body weight, usually well tolerated.
If you cancel a concomitant anticonvulsants topiramate monotherapy in order to take into account the possible impact of this step on the frequency of seizures. In cases where there is no need to topamax generic abruptly cancel the concomitant anticonvulsants for security reasons, it is recommended to reduce their dose gradually reducing the dose of concomitant antiepileptic drugs by one third every 2 weeks.
With the abolition of drugs that are inducers of hepatic enzymes, the concentration of topiramate in the blood will increase. In such situations, if clinically indicated dose of Topamax can be reduced.
In conducting monotherapy for adults, including elderly patients with normal renal function, at the beginning of treatment prescribed Topamax 25 mg 1 time per day. bedtime for 1 week. Then increase the dose at intervals of 1-2 weeks at 25-50 mg / day. 2 admission. If intolerance of such a treatment regimen increase the dose to a smaller size or with buy topamax no prescription large intervals. The dose is selected depending on the clinical effect. The initial dose is 100 mg, the maximum daily dose – 500 mg. In some cases, the form of refractory epilepsy patients tolerate Topamax monotherapy in doses up to 1000 mg / day.
When monotherapy for children older than 2 years in the first week of treatment prescribed topiramate at a dose of 0.5-1 mg / kg body weight before bedtime. Then increase the dose at intervals of 1-2 weeks to 0.5-1 mg / kg / day., The daily dose divided into 2 hours. If intolerance of such a regime can increase the dose to a smaller size or with large intervals. The value of dose and its rate of increase determined by the clinical effectiveness of therapy. The recommended dosage range for topiramate monotherapy in children older than 2 years is 3-6 mg / kg / day. In newly diagnosed partial seizures dose can be up to 500 mg / day.
For the prevention of migraine attacks daily dose of topiramate was 100 mg in 2 divided doses. At the beginning of topamax generic treatment prescribed by 25 mg at bedtime for 1 week. Then increase the dose of 25 mg at intervals of 1 week. If intolerance of such a treatment regimen increase the dose to a smaller size or with large intervals.
The dose is selected depending on the clinical effect. In some cases, a positive result is achieved at a daily dose of topiramate 50 mg. In clinical studies, patients received different doses, but not more than 200 mg / day.
Side effects
Side effects are shown with the distribution of frequencies and organ systems. The frequency of side effects were classified as follows: very common (≥ 1 / 10), common (≥ 1 / 100, <1 / 10), uncommon (≥ 1 / 1000 and <1 / 100), rare (≥ 1 / 10 000 and <1 / 1000) and very rarely (<1 / 10 000).
From the side of the central nervous system and peripheral nervous system: very often – drowsiness, dizziness, paresthesia, children – apathy, a violation of attention, often – loss of coordination, nystagmus, lethargy, impaired memory, violation of concentration, tremor, amnesia, poor gait, hypesthesia, perversion of taste, thought disorder, topamax generic, speech disorder, dysarthria, cognitive disorders, lethargy, mental impairment, psychomotor disorders, sedative effect; infrequently – the loss of taste sensitivity, akinesia, loss of smell, aphasia, burning sensation, cerebellar syndrome, a violation of the circadian rhythm of sleep, clumsiness, postural dizziness, increased salivation, numbness, dysgraphia, dyskinesia, dysphasia, crawl, hyperesthesia, gipogevziya, hypokinesia, buy topamax no prescription hyposphresia, peripheral neuropathy, parosmiya, presyncope, repetitive speech, paraphia, stupor, fainting, lack of response to stimuli in children – psychomotor hyperactivity.
Mental disorders: frequent – slow thinking, expressed by speech disturbances, confusion, depression, insomnia, aggressive reaction, agitation, irritability, dizorientatsiya, emotional lability, erektilnayaya dysfunction in children – changing behavior, learning disabilities, infrequent – anorgasmia, sexual dysfunction, apathy , the cries, the violation of sexual arousal, disfemiya, increased distractibility, early awakening in the morning, elated and euphoric mood, auditory and visual hallucinations, gipomaniakalnyoe state, a decrease topamax generic in libido, mania, a state of panic, paranoid state, perseveration of thought, a violation of Reading, restlessness, sleep disturbances, suicidal ideation or attempts, crying, very rarely – a sense of despair.
Also, there were nervousness, headache, psychomotor retardation, ataxia, additionally in children – personality disorder, hyperkinesia, rare – psychotic symptoms in children – hallucinations.
From the digestive system: very often – a reduction or increase of appetite, anorexia, frequent – nausea, diarrhea; rare – abdominal pain, constipation, stomach discomfort, dyspepsia, dry mouth, a violation of the sensitivity in the mouth, gastritis, gastroesophageal reflux, bleeding gums, heavy feeling in the stomach; infrequently – bad breath, discomfort in the epigastrium, flatulence, glossodiniya, pain in the mouth, hypersecretion buy topamax no prescription of the salivary glands, thirst, the children – vomiting rarely – increased activity of hepatic transaminases, hepatitis, liver failure .
From the Musculoskeletal System: Frequent – myalgia, muscle cramps, muscle cramps, muscle pain topamax generic in the chest, arthralgia; infrequently – the pain in his side, fatigue, weakness, muscle stiffness, very rarely – a swelling of the joints, discomfort in the limbs.
Since the cardiovascular system: Infrequent – bradycardia, palpitations, flushing, orthostatic hypotension, vibration disease.
On the part of the organ of vision: it is often – diplopia, blurred vision, dry eyes, infrequent – disturbance of accommodation, amblyopia, blepharospasm, transient blindness, unilateral blindness, increased lacrimation, mydriasis, night blindness, Photopsia, presbyopia, scintillating scotoma, scotoma, reduced visual acuity ; very rarely – unpleasant sensations in the eyes, angle-closure glaucoma, the violation of eye movements, swelling of eyelids, myopia.
The part of the organ of hearing: often – earaches, ringing in the ears, children – vertigo; infrequently – deafness, sensorineural deafness, unilateral deafness, discomfort in the ears, hearing loss.
On the part of the respiratory system: often – difficulty breathing, nose bleeding, infrequent – hoarseness, shortness of breath on exertion, nasal obstruction, hypersecretion in the paranasal sinuses in children – running nose, very rarely – nasopharyngitis.
Dermatological reactions: often – a rash, alopecia, pruritus, reduction in sensitivity person; infrequently – no sweats, allergic dermatitis, skin redness, pigmentation disorders of the skin, rashes, swelling of the face, an unpleasant smell of skin, rash, very rarely – a polymorphic erythema, pemphigus, periorbital edema, Stevens-Johnson syndrome, toxic epidermal necrolysis (especially when using in conjunction with topamax generic other drugs that cause adverse reactions from the skin and mucous membranes).
The part of the urinary system: often – nephrolithiasis, dysuria, thamuria; infrequently – urolithiasis, hematuria, urinary incontinence, frequent urge to urinate, renal colic, pain in the kidney, very rarely – pochechnokanaltsevy acidosis.
The part of the hemopoietic system: often – anemia; infrequently – leukopenia, lymphadenopathy, thrombocytopenia, topamax generic in children – eosinophilia; very rarely – neutropenia.
Laboratory findings: Infrequent – reduce the content of bicarbonate in the blood, crystalluria, hypokalemia, metabolic acidosis, hyperchloraemic acidosis.
General disorders: very common – fatigue, irritability, weight loss, often – asthenia, anxiety in children – fever infrequently – face edema, allergic reactions, cold extremities, very buy topamax no prescription rarely – generalized edema, influenza-like illness, allergic edema, conjunctival edema, weight gain.
Other: rarely – oligogidroz (mostly children).
Contraindications
*
Children under 2 years;
*
Hypersensitivity to the ingredients.
Precautions should be used in renal or hepatic insufficiency, nefrourolitiaze (including past or family history), and hypercalciuria.
Pregnancy and lactation
Studies that Topamax would be used for the treatment of pregnant women, were not conducted. Nevertheless, use topamax generic during pregnancy is only possible in cases where the anticipated benefits to the mother outweighs the potential risk to the fetus.
A limited number of observations suggest that topiramate is excreted in breast milk. If necessary, use Topamax in lactation period should settle the question of termination of breastfeeding.
Application for violations of liver function
Precautions should be applied to liver failure.
In patients with moderate and severe hepatic topamax generic impairment the plasma clearance is reduced.
Use in Renal Impairment
In the appointment of the drug to patients with moderately or severely impaired renal function expressed should be aware that in order to achieve the equilibrium state of this category of patients may need 10-15 days, as opposed to 4-8 days in patients with normal renal buy topamax no prescription function. Since topiramate is removed from plasma during hemodialysis, in the days of the meeting should be prescribed an additional dose equal to half the daily dose in 2 hours (before and after the procedure).
Precautions should be used in renal failure, nefrourolitiaze (including past or family history), and hypercalciuria.
Cautions
Cancel Topamax should be gradual, to minimize the possibility of increasing the frequency of seizures. When conducting clinical trials of the drug dose was reduced by 50-100 mg 1 time per week – for the treatment of adults with epilepsy and 25-50 mg – in adults receiving topamax generic in doses of 100 mg for the prevention of migraine.
The children in clinical trials Topamax gradually abolished within 2-8 weeks. If for medical reasons need quick removal of Topamax, it is recommended to exercise appropriate control of the patient. In some patients, removal of the drug has been accelerated and passed without any complications.
